.alpha.-Vinyl derivatives of .alpha.-amino acids

Details .alpha.-Vinyl derivatives of .alpha.-amino acids .alpha.-Vinyl derivatives of .alpha.-amino acids

Filed on

1977-07-01

Date issued

1979-04-03

Examiner

Trousof, Natalie

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

560171, 562426, 562448, 562450, 562565, 562571, 424319, 26032645, 260558A, 260559A, 260561A, 542416, 546243, 560 16, 560 39, 560 41, 560159, 560160, 560169, C07D21160, C07D20716, C07C10128

Type

Patent

Status

active

Patent number

041478738

Description

ABSTRACT:
Novel vinyl derivatives of .alpha.-amino acids of the following general structure: ##STR1## wherein R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR2## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; Z is R.sub.1 OCCH.dbd.CH-- or R.sub.1 OC(CH.sub.2).sub.n -- wherein n is an integer of from 1 to 3; each R.sub.1 is the same and is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms and can be the same or different, or ##STR3## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and the lactams thereof when Z is R.sub.1 OC(CH.sub.2).sub.n -- and n is 2 or 3; and pharmaceutically acceptable salts and individual optical isomers thereof.

REFERENCES:
patent: 2929836 (1960-03-01), Carrara
patent: 3197477 (1965-07-01), Gubitz
patent: 3946074 (1976-03-01), Abramitis
patent: 3960927 (1976-06-01), Metcalf et al.
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, p. 335.

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