Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-03-03
1997-06-17
Stanton, Brian R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
435 691, 435 696, 435 697, 435 698, 435 711, 4351723, 514 44, 800DIG1, 800DIG4, 800DIG6, 935 47, 935 48, 935 53, 935 55, 935 70, C12N 510, C12N 1506, C12N 1509, C12P 2102
Patent
active
056399405
ABSTRACT:
Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A.alpha., B.beta. and .gamma. chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.
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Dalrymple Michael L.
Foster Donald C.
Garner Ian
Prunkard Donna E.
Leith Debra K.
Parker Gary E.
Pharmaceutical Proteins Ltd.
Sawislak Deborah A.
Stanton Brian R.
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