Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2007-09-18
2007-09-18
Foley, Shanon (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S186100, C530S300000, C530S350000
Reexamination Certificate
active
10193142
ABSTRACT:
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusion proteins of the invention have are useful as antigens for inducing the production of antibodies having desired binding properties, e.g., protective antibodies, or for use as vaccine antigens for the induction of protective immunity against the parvovirus. Feline parvovirus epitopes were fused to the N-terminus of the TMV coat protein, expressed inNicotianaplants, extracted, purified, characterized and administered to animals, resulting in protective immunity.
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Garger Stephen J.
Gross Cynthia S.
Lawrence Jonathan E.
Lindbo John A.
McCulloch Michael J.
Fitzmaurice Wayne P.
Foley Shanon
Large Scale Biology Corporation
Tarcza John E.
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