Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2008-07-15
2008-07-15
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S330000, C514S275000
Reexamination Certificate
active
10523753
ABSTRACT:
Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise:a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent;b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent;c) dehydrating the corresponding amide of the compound of formula (I).
REFERENCES:
patent: WO 01/85700 (2001-11-01), None
patent: WO 03016306 (2003-02-01), None
International Search Report dated Nov. 6, 2003 for corresponding Appln. No. PCT/EP 03/50366.
International Preliminary Examination Report dated Nov. 30, 2004 for corresponding Appln. No. PCT/EP 03/50366.
Guillemont Jérôme Emile Georges
Heeres Jan
Janssen Paul Adriaan Jan
Leenders Ruben Gerardus George
Medaer Bart Petrus Anna Maria Jozef
Balasubramanian Venkataraman
Donnelly Laura
Janssen Pharmaceutica N.V.
LandOfFree
Processes for the preparation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Processes for the preparation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Processes for the preparation of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3918800