Processes and intermediates for making 16-phenoxy and 16-substit

Details Processes and intermediates for making 16-phenoxy and 16-substit Processes and intermediates for making 16-phenoxy and 16-substit

1983-12-22

1986-07-15

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549422, 556441, 558426, C07C17700

Patent

active

046007857

ABSTRACT:
This invention relates to a process for making an enantiomer or racemic mixture of a compound of the formula ##STR1## wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, and the wavy lines represent the .alpha. or .beta. configuration with the proviso that when one wavy line is a .alpha. the other is .beta.; novel intermediates useful for preparing these compounds; and processes for making the intermediates.

REFERENCES:
patent: 4304907 (1981-12-01), Nelson
patent: 4389414 (1983-06-01), Kent
Mori, K. et al., Tetrahedron vol. 37, pp. 1343-1347, 1981.
Vickery, B. H. et al., Prostaglandins Med. 5(2), 93-100, 1980.
Johnson, D. M. et al., J. Pharm. Sci. 72(8), 946-8, 1983.

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