Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1997-03-28
1998-11-17
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544369, 548217, 548221, 548229, 548257, C07D41304, C07D24916
Patent
active
058378707
ABSTRACT:
The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).
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Barbachyn Michael R.
Fleck Thomas J.
Houser David J.
Manninen Peter R.
Pearlman Bruce A.
Pharmacia & Upjohn Company
Richter Johann
Sackey Ebenezer
Stein Bruce
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