Process of wound healing using PDGF and EGF

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 8, 514 21, A61K 3702, A61K 3736

Patent

active

050343750

ABSTRACT:
Healing an external wound of a mammal by administering to the mammal a composition containing purified EGF and purified PDGF in a weight to weight ratio of at least 5:1.

REFERENCES:
patent: 4085204 (1978-04-01), Wacker et al.
patent: 4350687 (1982-09-01), Lipton et al.
patent: 4479896 (1984-10-01), Antoniades
patent: 4604234 (1986-08-01), Fujii et al.
patent: 4702908 (1987-10-01), Thorbecke et al.
patent: 4742003 (1988-05-01), Derynck et al.
patent: 4745179 (1988-05-01), Ueda et al.
Betsholtz et al., "Growth Factor-Induced Proliferation of Human Fibroblasts in Serum-Free Culture Depends on Cell Density and Extracellular Calcium Concentration," J. of Cellular Physio., 118: 203-210 (1984).
Canalis, "Effect of Platelet-Derived Growth Factor on DNA and Protein Synthesis in Cultured Rat Calvaria," Metabolism, 30: 970-975 (1981).
Clemmons et al., "Somatomedin-C and Platelet-Derived Growth Factor Stimulate Human Fibroblast Replication," J. of Cellular Physio., 106: 361-367 (1981).
Computer print out of various patent abstracts.
Grotendorst, "Can Collagen Metabolism Be Controlled?", J. of Trauma 24: 549-552 (1984).
Grotendorst et al., "Molecular Mediators of Tissue Repair," in Soft and Hard Tissue Repair, Hunt et al. eds., Praeger Scientific, 1984, pp. 20-40.
Grotendorst et al., "Stimulation of Granulation Tissue Formation by Platelet-Derived Growth Factor in Normal and Diabetic Rats," J. Clin. Invest. 76: 2323-2329 (1985).
Hebda, "The Effects of Peptide Growth Factors on Epidermal Outgrowth in an in Vitro Wound Healing Model", J. of Cell Biology, 107: p. 46A (1989).
Heldin et al., "Growth of Normal Human Glial Cells in a Defined Medium Containing Platelet-Derived Growth Factor," Proc. Natl. Acad. Sci. U.S.A., 77: 6611-6615 (1980).
Kabigen Commercial literature, "Human Cell Growth Factors for Cell Growth and Differentiaton".
Lawrence et al., "The Reversal of an Adriamycin Induced Healing Impairment with Chemoattractants and Growth Factors," Ann. Surg., 203: 142-147 (1986).
Leal et al., "Evidence That the V-Sis Gene Product Transforms by Interaction with the Receptor for Platelet-Derived Growth Factor," Science, 230: 327-330 (1985).
Leitzel et al., "Growth Factors and Wound Healing in the Hamster," J. Dermatol. Surg. Oncol., 11: 617-621 (1985).
Lynch et al., "Role of Platelet-Derived Growth Factor in Wound Healing: Synergistic Effects With Other Growth Factors," Proc. Natl. Acad. Sci. U.S.A., 84: 7696-7700 (1987).
Michaeli et al., "The Role of Platelets in Wound Healing: Demonstration of Angiogenic Activity," Soft and Hard Tissue Repair, Hunt et al., eds., Praeger Scientific, 1984 pp. 380-394.
Mustoe et al., "Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-B," Science, 237: 1333-1336 (1987).
Roberts et al., "Type B Transforming Growth Factor: A Bifunctional Regulator of Cellular Growth," Proc. Natl. Acad. Sci. U.S.A., 82: 119-123 (1985).
Reddan et al., "Insulin-Like Growth Factors, IGF-1, IGF-2 and Somatomedin C Trigger Cell Proliferation in Mammalian Epithelial Cells Cultured in a Serum-Free Medium," Exp. Cell Res., 142: 293-300 (1982).
Rinderknecht et al., "Primary Structure of Human Insulin-Like Growth Factor II," Proc. Natl. Acad. Sci. U.S.A., 89: 283-286 (1978).
Ross et al., "The Biology of Platelet-Derived Growth Factor," Cell, 46: 155-169 (1986).
Schultz et al., "Epithelial Wound Healing Enhanced by Transform Growth Factor," Chemical Abstracts, 106: 96915h (1987).
Shipley et al., "Reversible Inhibition of Normal Human Prokeratinocyte by Type B Transforming Growth Factor-Growth Inhibitor in Serum-Free Medium," Cancer Research, 46: 2068-2071 (1986).
Sporn et al., "Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo," Science, 219: 1329-1331 (1983).
Sporn et al., "Repair of Tissue in Animal", U.S. Ser. No. 468,590, date filed 2/22/83.
Stiles et al., "Dual Control of Cell Growth by Somatomedins and Platelet Derived Growth Factor," Proc. Natl. Acad. Sci. U.S.A., 76: 1279-1283 1979.
Tashjian et al., "Platelet-Derived Growth Factor Stimulates Bone Resorption via a Prostaglandin-Mediated Mechanism," Endocrinology, 111: 118-124 (1982).
Van Wyk et al., "Role of Somatomedin in Cellular Proliferation in The Biology of Normal Human Growth," edited by M. Ritzen et al., Raven Pres. pp. 223-239 (1981).
Devel et al., (1984) J. Clin. Invest. 74:669.

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