Food or edible material: processes – compositions – and products – Products per se – or processes of preparing or treating... – Protein – amino acid – or yeast containing
Patent
1996-10-09
1998-04-07
Pratt, Helen
Food or edible material: processes, compositions, and products
Products per se, or processes of preparing or treating...
Protein, amino acid, or yeast containing
426 74, 426601, 426656, 426658, A23L 1305, A23L 1304
Patent
active
057361878
DESCRIPTION:
BRIEF SUMMARY
The invention concerns a process for the production of a phenylalanine-free nutrient base for infants and small children, which in addition to an amino acid mixture which has all L-amino acids necessary for the nutrition of the child, except for phenylalanine, also contains fat(s) and/or carbohydrates and also, optionally, minerals and/or trace elements, wherein an aqueous formulation containing these components is spray-dried.
Phenylketonuria (referred to below as PKU) is among the genetically determined diseases, and is a metabolic disorder. For treatment of this metabolic disorder, a child suffering from PKU normally receives a food which contains a limited amount of natural protein and just so much phenylalanine as the child's body needs for building up protein (growth).
However, such a low phenylalanine diet alone would provide the children with too little of all other amino acids, just as important for life. Hence these children are given special products, which are mixtures of L-amino acids or of specific extremely low-phenylalanine proteins or protein hydrolysates. In addition, vitamins, minerals and trace elements are incorporated in these mixtures.
Now the diet of an infant suffering from PKU consists of a bottle-food, which is made up of adapted infant milk-food and/or breast milk and a phenylalanine-free infant nutrient base.
Such a phenylalanine-free nutrient base for infants and small children is known from German patent application P 40 42 115.5 and European patent application EP-A 0 492 138. In these publication, the problems connected with PKU and its treatment are explained in more detail. Reference is thus expressly made to the disclosures of these publications.
In the production of the phenylalanine-free nutrient bases for infants and small children nutrient bases described in the aforesaid two publications, the amino acids, which are mainly used as free acids, together with the other constituents, for example fats and carbohydrates, etc., are incorporated into an aqueous formulation, which is then spray-dried.
In the spray-drying of these known, complete nutrient bases which are based on amino acids, the problem then arose that chemical reactions took place, so that the amino acid analysis of the final product departed from the values theoretically to be expected, and undesired byproducts arose. Hence the aim of the present invention is to provide a process for the production of a nutrient base for infants and small children and such a nutrient base itself which can be obtained by spray-drying, where during this spray-drying as few undesired by-products as possible arise or are formed.
This aim is achieved by the teaching of claim 1 and claim 8 respectively.
It has now surprisingly been found that a phenylalanine-free nutrient base for infants and small children which contains as few by-products as possible can be obtained by spray-drying of an aqueous formulation, if at least the amino acids lysine and cystine are at least in part not spray-dried with this formulation, but are mixed with or added into the spray-dried product later.
According to the invention, the whole amount of the amino acids lysine and/or cystine can be mixed with the already spray-dried product. However it is also possible to add part of the lysine and/or cystine to the wet formulation to be spray-dried, and then only later to mix in the remainder dry. Here the amount of lysine and/or cystine which is added to the wet formulation to be spray-dried should not make up more than 10% of the total amount of lysine and/or cystine used.
Hence it is sufficient according to the invention to "leave out" only one of the two amino acids lysine and cystine during the spray-drying and only later mix it in dry. In this case also, up to 10% of the total amino acid lysine or cystine used can be subjected to the spray-drying process. With this procedure, fewer undesired by-products already arise than in the product according to the state of the technology. Preferably, however, both amino acids lysine and cystine are left out during
REFERENCES:
patent: 5393532 (1995-02-01), Wachtel
patent: 5411757 (1995-05-01), Buist et al.
patent: 5547687 (1996-08-01), Outinen
Raffler Gunther
Schweikhardt Friedrich
Tesmer Erhard
Vetter Marianne
Milupa GmbH & Co. KG
Pratt Helen
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