Process improvements in steroid chemistry

Details Process improvements in steroid chemistry Process improvements in steroid chemistry

2006-01-03

2006-01-03

Badio, Barbara P. (Department: 1617)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C552S612000

Reexamination Certificate

active

06982329

ABSTRACT:
Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding α,β-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the α,β-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.

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