Process for the synthesis of the disodium salt hemiheptahydrate

Details Process for the synthesis of the disodium salt hemiheptahydrate Process for the synthesis of the disodium salt hemiheptahydrate

1993-02-19

1996-11-12

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50136

Patent

active

055741550

ABSTRACT:
The invention relates to a new process for the production of the disodium salt hemiheptahydrate of ceftriaxone by reacting 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio] methyl}-3-cephem-4-carboxylic acid with 2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetic acid-(2-benzthiazolyl)thiolester in the presence of a base, characterized in that the reaction and the crystallization of the disodium salt hemiheptahydrate of ceftriaxone are carried out in aqueous acetone.

REFERENCES:
patent: 4327210 (1982-04-01), Montaum et al.
patent: 4758556 (1988-07-01), Durckheimer et al.
patent: 4767852 (1988-08-01), Ascher
patent: 5026843 (1991-06-01), Riccardo et al.
patent: 5126445 (1992-06-01), Martin
Chem. Abst. 99, 70458 (1983).

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