Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1984-10-15
1986-10-21
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
2603971, A61K 3156
Patent
active
046186050
ABSTRACT:
Disclosed is a process for the production of .beta.-elemonic acid from an alcoholic solution of gum elemi by recovering a crude mixture of elemi acids containing .beta.-elemonic acid, .DELTA..sup.7 .alpha.-elemonic acid and .DELTA..sup.8 .alpha.-elemolic acid by the use of a basic ion exchanger, isomerizing the .DELTA..sup.7 .alpha.-elemolic acid to .DELTA..sup.8 .alpha.-elemolic acid in a chlorinated hydrocarbon by use of a mineral acid, oxidizing the .DELTA..sup.8 .alpha.-elemolic acid to yield additional .beta.-elemonic acid and separating and purifying the total resulting .beta.-elemonic acid from the acid mixture. Also disclosed are pharmaceutical preparations for the treatment of inflammatory conditions containing .beta.-elemonic acid as the active ingredient.
REFERENCES:
"Steroids" (1959), by Fieser et al, pp. 397-398.
Fieser and Fieser, "Steroide", Verlag Chemie (1961), pp. 436-437.
Halsall, et al., J. of Chem. Soc., "The Chemistry of the Triterpenes and Related Compounts . . . Some Aspects of the Chemistry of the Elemi Acids", pp. 4139-4148 (1953).
Hagers Handbuch der Pharmazeutischen Praxis, vol. 4, pp. 765-755 (1973).
Birkner Christian
Christ Bruno
Gober Karl-Heinz
Kesselring Kurt
Leyck Sigurd
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