Process for the production of 5-(4'-chloro-5'-sulfamoyl-2'-theny

Details Process for the production of 5-(4'-chloro-5'-sulfamoyl-2'-theny Process for the production of 5-(4'-chloro-5'-sulfamoyl-2'-theny

1981-08-04

1983-05-31

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

542423, C07D25704

Patent

active

043862128

ABSTRACT:
The present invention provides a process for the preparation of 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole by condensing 5-(4'-chloro-5'-sulfamoyl-2'-aminophenyl)-tetrazole with thiophene-2-aldehyde in the presence of an acid catalyst and reducing the 5-[4'-chloro-5'-sulfamoyl-2'-(thenylidene-2-amino)-phenyl]tetrazole so obtained with a boranate, wherein the condensation is carried out in dimethyl sulfoxide as solvent, with azeotropic distilling off of the water formed and the reduction is carried out in the same medium, without isolation of the 5-[4'-chloro-5'-sulfamoyl-2'-(thenylidene-2-amino)-phenyl]-tetrazole.

REFERENCES:
patent: 3665002 (1972-05-01), Popelak
Cram et al., Org. Chem., p. 379, McGraw Hill, N.Y., N.Y., (1964).
Organic Syn., vol. I, p. 80.

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