Process for the production of 4-amino-6,7-dimethoxy-2-[4-(furo-2

Details Process for the production of 4-amino-6,7-dimethoxy-2-[4-(furo-2 Process for the production of 4-amino-6,7-dimethoxy-2-[4-(furo-2

1984-03-16

1987-03-03

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Imidate esters

544291, 544398, C07C12726

Patent

active

046476849

ABSTRACT:
The invention relates to a new multistage process for the production of 4-amino-6,7-dimethoxy-2-[4-(furo-2-yl)-piperazin-1-yl]-quinazoline corresponding to the following formula ##STR1## and physiologically compatible salts thereof, which gives better yields and uses less expensive and more reactive materials than known processes. The intermediate product formed in this process, N"-cyano-N'-(3,4-dimethoxyphenyl)-O-phenylisourea, shows antihypertensive activity on its own.

REFERENCES:
patent: 4001237 (1977-01-01), Partyka et al.
patent: 4138651 (1979-02-01), Crenshaw
patent: 4578389 (1986-03-01), Schickaneder et al.

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