Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(

Details Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-( Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(

1985-07-24

1987-08-04

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 921

Patent

active

046847421

ABSTRACT:
Process for production of racemic or enantiomeric form of 2-(2-halogenoethylamino)-2-oxo-3-(2-halogenoethyl)-1.3.2.-oxazaphosphorina nes of general formula 1, ##STR1## wherein X and Y are the same or different and represent halogen atoms is based, according to invention, on the reaction of enantiomeric or racemic form of ethyleneimide of general formula 2, ##STR2## wherein Y is the same as above, with aqueous solution of hydrogen halide. Compounds of general formula 1, where X and Y are different and represent halogen atoms, possess better antileukemic activity than ifosfamide.

REFERENCES:
Asta-Werke, "Chem. Abstracts", vol. 71, (1969), 49998m, Abstract of French Pat. No. 1,530,962, 6/28/68.
Lassauniere et al, "Chem. Abstracts", vol. 71, (1969), 30585c, Abstract of French Pat. No. 1,537,175, 8/23/68.

Affiliated with

Also associated with

Rating

Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-( does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-( will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-884704