Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(

Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters

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C07F 921

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046847421

ABSTRACT:
Process for production of racemic or enantiomeric form of 2-(2-halogenoethylamino)-2-oxo-3-(2-halogenoethyl)-1.3.2.-oxazaphosphorina nes of general formula 1, ##STR1## wherein X and Y are the same or different and represent halogen atoms is based, according to invention, on the reaction of enantiomeric or racemic form of ethyleneimide of general formula 2, ##STR2## wherein Y is the same as above, with aqueous solution of hydrogen halide. Compounds of general formula 1, where X and Y are different and represent halogen atoms, possess better antileukemic activity than ifosfamide.

REFERENCES:
Asta-Werke, "Chem. Abstracts", vol. 71, (1969), 49998m, Abstract of French Pat. No. 1,530,962, 6/28/68.
Lassauniere et al, "Chem. Abstracts", vol. 71, (1969), 30585c, Abstract of French Pat. No. 1,537,175, 8/23/68.

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