Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing
Patent
1996-01-22
1998-09-15
Robinson, Allen J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Cyclopentanohydrophenanthrene ring system containing
C07J 700
Patent
active
058081178
ABSTRACT:
The invention relates to a process for producing 16-Dehydropregnenolone acetate (16DPA) of the formula shown below ##STR1## which process comprises a) acetolysis of diosgenin of the formula shown below ##STR2## by heating in a pressure reactor in the presence of an acetylating agent and a non-polar solvent, maintaining the pressure in the reactor in the range of 4-6 kg/cm.sup.2 and at a temperature in the range of 200.degree.-250.degree. C. to produce pseudodiosgenine acetate of the formula shown below ##STR3## b) Oxidizing the so obtained pseudodiosgenin acetate to obtain diosone of the formula shown below ##STR4## and, c) Hydrolysis and degradation of the diosone so obtained to produce the said 16-Dehydropregnenolone acetate.
REFERENCES:
patent: 3136758 (1964-06-01), Chemerda et al.
patent: 4482706 (1984-11-01), Tomimatsu et al.
Baraua Nabin Chandra
Baruah Ajoy Pratap
Bordoloi Manobjyoti
Chowdhury Pritish Kumar
Ghosh Anil Chandra
Badio Barbara
Borsari Peter A.
Robinson Allen J.
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