Process for the preparation of pharmaceutically acceptable...

Details Process for the preparation of pharmaceutically acceptable... Process for the preparation of pharmaceutically acceptable...

2005-10-25

2005-10-25

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

Reexamination Certificate

active

06958233

ABSTRACT:
The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine and allows to obtain the salified (R)-(+)-S-adenosyl-L-methionine diasteroisomer in amounts lower than or equal to 3% with respect to the salified (S)-(+)-S-adenosyl-L-methionine diastereoisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.

REFERENCES:
patent: 3954726 (1976-05-01), Fiecchi
patent: 4621056 (1986-11-01), Gennari
patent: 2 531 714 (1984-02-01), None
Caonline Registry citation of S-adenosyl-L-methionine and chemical structure.
WordIQ.com definition of Room and Ambient Temperature.
J.L. Hoffman, “Chromatographic analysis of the chiral and covalent instability of S-adeosyl-L-methionine” BIOCHEMISTRY, vol. 25, 1986, pp. 4444-4449.
Mark L. Stolowitz and M.J. Minch, S-Adenosyl-L-methionine and S-Adenosyl-L-homocysteine, and NMR Study1, Received Apr. 13, 1981, pp. 6015-6019.
John Warcup Cornforth,1a,bScott A. Reichard, 1cPaul Talalay,1,cH. L. Carrell,1dand Jenny P. Glusker1d, Determination of the Absolute Configuration at the Sulfonium Center of S-Adenosylmethionine. Correlation with the Absolute Configuration of the Diasteromeric S-Carrboxymethyl-(S)-methionine Salts, Received Apr. 25, 1977, pp. 7292-7300.
Creason et al., “Soybeans andRadish Leaves Contain Only One of the Sulfonium Diasteroisomers of S-Adenosylmethionine”, Phytochemistry 24 (6) : 1151-1155 (1985).
Matos et al., “S-Adenosylmethionine: Stability and Stabilization”, Bioorganic Chemistry 15: 71-80 (1987).

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