Process for the preparation of optically pure R (−)...

Details Process for the preparation of optically pure R (−)... Process for the preparation of optically pure R (−)...

2006-09-25

2011-11-22

Davis, Brian J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S304000, C564S438000

Reexamination Certificate

active

08063251

ABSTRACT:
A process for the preparation of optically pure R (−) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1to C4branched or normal chain alcohol for dissolution of the racemic mixture and resolving agent and purification of the 4-nitro tartranilic acid salt of R (−) salbutamol. 4-nitro tartranilic acid salt of R (−) salbutamol is converted into formic acid salt of R (−) 4-benzyl salbutamol followed by basification and debenzylation to form optically pure R (−) salbutamol. Optically pure (R)-salbutamol is obtained in good yield and high purity. The optically pure R (−) salbutamol is optionally converted into pharmaceutically acceptable salts.

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