Process for the preparation of optically active cyclopropane car

Details Process for the preparation of optically active cyclopropane car Process for the preparation of optically active cyclopropane car

1983-11-25

1985-04-02

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562506, C07B 1900

Patent

active

045089191

ABSTRACT:
The invention relates to a process for the preparation of enantiomers of trans vinyl-cyclopropane carboxylic acids of the formula I, ##STR1## wherein R is a methyl group or chlorine atom, by resolution of racemic trans compound or mixture of racemic cis and trans compounds by using (+)- or (-)-N-(1-formamido-2,2,2-trichloroethyl)-piperazine as a resolving agent in a polar solvent then separating the crystallizing salt of (+)-trans carboxylic acid and (-)-resolving agent or (-)-trans carboxylic acid and (+)-resolving agent from the mother liquor by filtration and obtaining the enantiomers by acidifying the mother liquor or the salts suspended in water followed by extraction with a solvent and evaporation.
The products so obtained may be used as starting materials for the preparation of insecticides.

REFERENCES:
patent: 4196304 (1980-04-01), Naumann
patent: 4229593 (1980-10-01), Kondo et al.
patent: 4328173 (1982-05-01), Jolly et al.

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