Process for the preparation of meso 2,5-dihaloadipates

Details Process for the preparation of meso 2,5-dihaloadipates Process for the preparation of meso 2,5-dihaloadipates

1987-08-07

1988-04-05

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560191, 562593, 562596, C07C 6714, C07C 6752

Patent

active

047360593

ABSTRACT:
The present process produces the meso dialkyl 2,5-dihaloadipate from a mixture of the racemic dialkyl 2,5-dihaloadipate and meso 2,5-dihaloadipate. In the disclosed process, a 2,5-dihaloadipoyl halide is formed under conditions which result in the formation of an acidic compound. The 2,5-dihaloadipoyl halide is then esterified under conditions wherein the ester of the dihaloadipoyl halide is allowed to remain in contact with the acidic compound, thus allowing the racemic diester to epimerize in the presence of the acidic compound to the meso form and then the meso diester spontaneously crystallizes. In the last stage, the meso diester produced is removed.

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