Process for the preparation of insulin conjugate IN-105

Details Process for the preparation of insulin conjugate IN-105 Process for the preparation of insulin conjugate IN-105

2005-10-13

2011-11-15

Stoica, Elly-Gerald (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

C530S303000, C530S304000, C530S402000, C530S412000, C530S416000, C424S124000, C514S006300, C514S006400

Reexamination Certificate

active

08058391

ABSTRACT:
The invention claims a process for making an insulin-oligomer conjugate IN-105. IN-105 precursor having formula G-A-V-R-[B-Chain]-R-D-A-D-D-R-[A-Chain] is cloned and expressed inPichia. The biosynthetic precursor is then conjugated with an activated oligomer. The IN-105 precursor-oligomer conjugate is then treated with protease and purified to afford active insulin-oligomer conjugate of formula insulin-OC—CH2—CH2—(OCH2CH2)3—OCH3.

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