Process for the preparation of high purity buspiron and the hydr

Details Process for the preparation of high purity buspiron and the hydr Process for the preparation of high purity buspiron and the hydr

1994-07-14

1995-12-05

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40304

Patent

active

054730724

ABSTRACT:
Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-d ione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7 ,9-dione thus obtained into the hydrochloride thereof.

REFERENCES:
patent: 5334715 (1994-08-01), Ong et al.
Kojima et al., Chemical Abstracts, 110(3):23,914e, 1989, abstract of JP 6310760 (18 Jan. 1988).
Kuo et al., Chemical Abstracts, 120(13):164,231y, abstract of CH 682,563 (15 Oct. 1993).
Kuo et al, Heterocycles, 36(7), 1463-1469, (1993).
Budai et al, Chemical Abstracts 110(5):39,018b, abstract of DE 3,806,009 (25 Feb. 1987).

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