Process for the preparation of desulfatohirudins

Details Process for the preparation of desulfatohirudins Process for the preparation of desulfatohirudins

1984-11-21

1987-03-31

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

530324, 514 12, C12P 2102, C07C10352, A61K 3702, C07K 710

Patent

active

046543023

ABSTRACT:
The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof.
The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.

REFERENCES:
Walsmann et al., Die Pharmazie, 36, 653-660 (1981).
P. D. Boyer, The Enzymes, 3rd Ed. Academic Press, New York, vol. 5, pp. 21-41 (1971).

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