Process for the preparation of anti-hypertensive benzopyran

Details Process for the preparation of anti-hypertensive benzopyran Process for the preparation of anti-hypertensive benzopyran

1991-12-17

1993-06-29

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549400, 549401, C07D40504, C07D31172

Patent

active

052236293

ABSTRACT:
A process is disclosed for the preparation of (.+-.)-6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrol idino)-2H-1-benzopyran-3-ol of the Formula (VI) ##STR1## from 4-cyanophenol of the Formula (I) ##STR2## which comprises reacting 4-cyanophenol of the Formula (I) with isoprene, followed with bromination and dehydrobromination steps with formation of intermediates to react with 2-pyrrolidone resulting in obtaining the compound of the Formula (VI).

REFERENCES:
patent: 4214963 (1980-07-01), Blanco
patent: 4446113 (1984-05-01), Evans
patent: 5013853 (1991-05-01), Gericke et al.
Bolzoni et al. "selective in reactions . . . " Angew. Chem. Int. Ed. English 17 (1978) 684-686.
Bergmann et al. "Synthesis . . . " J. Med. Chem. 33 (2) 492-504 (1990).
Nebergall et al. "College Chemi . . . " Heath and Co. pp. 324-325 (1968).

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