Process for the preparation of anti-hypertensive benzopyran deri

Details Process for the preparation of anti-hypertensive benzopyran deri Process for the preparation of anti-hypertensive benzopyran deri

1990-06-25

1992-09-08

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549398, 549399, C07D40504

Patent

active

051459850

ABSTRACT:
A process is disclosed for the preparation of (.+-.)-6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrol idino)-2H-1-benzopyran-3-ol of the Formula (VI) ##STR1## from 4-cyanophenol of the Formula (I) ##STR2## which comprises reacting 4-cyanophenol of the Formula (I) with isoprene, followed with bromination and dehydrobromination steps with formation of intermediates to react with 2-pyrrolidone resulting in obtaining the compound of the Formula (VI).

REFERENCES:
patent: 4214963 (1980-07-01), Blanco
patent: 4391815 (1983-07-01), Evans
patent: 4446113 (1984-05-01), Evans
patent: 4716238 (1987-12-01), Timar et al.
Bolzoni et al., "Selective in Reactions . . . ", Angew Chem. Int. ed. Engl. 17 (1978) 684-686.
Caserio, "Basic Principle of Organic Chemistry", CIT Ed., pp. 306-310 (1964).

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