Process for the preparation of alkylphosphocholines and the prod

Details Process for the preparation of alkylphosphocholines and the prod Process for the preparation of alkylphosphocholines and the prod

1997-09-25

1999-08-24

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558166, C07F 910

Patent

active

059426390

ABSTRACT:
A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.

REFERENCES:
patent: 4130571 (1978-12-01), Nakajima et al.
patent: 4492659 (1985-01-01), Bosies et al.

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