Process for the preparation of 7-amino-cephem compounds using mo

Textiles: fiber preparation

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195 36C, C12D 904

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active

041417909

ABSTRACT:
Compounds are provided having the general formula I: ##STR1## wherein X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue. The formula I compounds are prepared from compounds of the general formula II: ##STR2## wherein R.sub.1 represents hydrogen, a lower alkanoyl group, an arylalkanoyl group, an alkoxycarbonyl group, a lower haloalkoxycarbonyl group, a substituted or unsubstituted aroyl group, a N-arylcarbamoyl group of a substituted or unsubstituted aryl group; R.sub.2 either represents hydrogen or, together with the ##STR3## group, represents a phthalimido group; and X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue, or their metal salts or their salts with organic bases, by causing the culture of a cephalosporin C acylase-producing strain of a microorganism, especially a mold, fungus, or the secondary preparation therefrom, to act on the latter compounds II in the presence of an aqueous medium.

REFERENCES:
patent: 3239394 (1966-03-01), Walton
patent: 3749641 (1973-07-01), Takahashi et al.
patent: 3930949 (1976-01-01), Kutzbach et al.
patent: 3962036 (1976-06-01), Liersch et al.

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