Process for the preparation of 7-(2-amino-2-phenylacetamido) cep

Details Process for the preparation of 7-(2-amino-2-phenylacetamido) cep Process for the preparation of 7-(2-amino-2-phenylacetamido) cep

1982-05-07

1984-02-21

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 29, 424246, C07D50104, C07D54429

Patent

active

044331428

ABSTRACT:
Improved process for the preparation of 7-(2-amino-2-phenyl-acetamido)cephem derivatives of the general formula (I): ##STR1## wherein R.sub.1 is a hydrogwn atom or hydroxyl group, n stands for 0, 1 or 2, and A denotes a nitrogen-containing heterocyclic group or a direct bond coupling directly the sulfur atom and the --(CH.sub.2).sub.n COOH group together, as well as pharmaceutically acceptable salts thereof. The process is not only simple and easy to carry out, but also provides as crystalline precipitate the intended products with a high yield. The 7-(2-amino-2-phenyl-acetamido)cephem derivatives are useful as intermediates for syntheses of antibacterial agents.

REFERENCES:
patent: 4148817 (1979-04-01), Wright

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