Process for the preparation of 3-acetamido-5-amino-2,4,6-triiodo

Details Process for the preparation of 3-acetamido-5-amino-2,4,6-triiodo Process for the preparation of 3-acetamido-5-amino-2,4,6-triiodo

1974-05-17

1976-11-09

Sutto, Anton H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10168

Patent

active

039911055

ABSTRACT:
The invention provides a process for the preparation of 3-acetamido-5-amino-2,4,6-triiodobenzoic acid substantially free from diiodinated material, in which 3-acetamido-5-aminobenzoic acid or a salt thereof is gradually introduced into an aqueous acid system which contains an excess of iodine chloride (ICl) in a stabilized form. In particular, the gradual introduction of 3-acetamido-5-aminobenzoic acid may be achieved by using 3,5-diacetamidobenzoic acid as starting material, the acid medium effecting hydrolysis of one acetamido group and the excess iodinating reagent reacting selectively at such a rapid rate that the desired triiodinated product is formed and precipitated without further hydrolysis or premature precipitation of unwanted diiodinated products.

REFERENCES:
patent: 2895988 (1959-07-01), Archer et al.
patent: 3133116 (1964-05-01), Larson
patent: 3647864 (1972-03-01), Ackerman
patent: 3734953 (1973-05-01), Bernstein et al.

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