Process for the preparation of 2-(methylsulfonyl)-5-(trifluorome

Details Process for the preparation of 2-(methylsulfonyl)-5-(trifluorome Process for the preparation of 2-(methylsulfonyl)-5-(trifluorome

1998-09-16

2000-02-29

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D28512

Patent

active

060311088

ABSTRACT:
The present invention provides a process for making thiadiazole sulfones. In particular, the present process is used to make 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole using catalytic oxidation in the presence of a suitable oxidizing agent. The catalyst system used for the oxidation reaction is a mixture of glacial acetic acid and a tungsten catalyst. The tungsten catalyst is preferably selected from the group consisting of sodium tungstate, potassium tunstate, and tungstic acid.

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patent: 4432847 (1984-02-01), Fields
patent: 4992456 (1991-02-01), Diehr et al.
Durst, T., in Comprehensive Organic Chemistry: Chapter 11.6, Barton and Ollis, Eds., Pergammon Press, Oxford, (month unavailable) 1979. (pp. 121-156).

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