Process for the preparation of 2-diazo-3-trisubstituted silyloxy

Details Process for the preparation of 2-diazo-3-trisubstituted silyloxy Process for the preparation of 2-diazo-3-trisubstituted silyloxy

1992-03-02

1994-08-23

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Diazo or diazonium

C07C24518

Patent

active

053409272

ABSTRACT:
A novel process for preparing 2-diazo-3-trisubstituted silyloxy-3-butenoates, synthons useful in the conversion of 3-substituted-4-acetoxy azetidinones and penicillin to thienamycin, imipenem and other carbapenem antibiotic compounds is provided, comprising the reaction of the appropriate diazo acetoacetate with the substituted silane, base and salt.

REFERENCES:
patent: 4444685 (1984-04-01), Amato et al.
patent: 4525582 (1985-05-01), Amato et al.
patent: 4683296 (1987-07-01), Ueda et al.
patent: 5071966 (1991-12-01), Kan et al.
Ceazeau et al. Tetrahedron, 43: 2075-2088 (1987).
Karady et al. J. Am. Chem. Soc. 103: 6765-6767 (1981).
Reider et al. Tetrahedron Lett., 23: 379-382 (1982).
Ueda et al., Can. J. Chem., 62: 2936-2940 (1984) IV.

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