Process for the optical resolution of d,l-2-amino-4-methylphosph

Details Process for the optical resolution of d,l-2-amino-4-methylphosph Process for the optical resolution of d,l-2-amino-4-methylphosph

1979-09-27

1980-10-07

Therkorn, Ernest G.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C07B 1902

Patent

active

042269415

ABSTRACT:
L-2-Amino-4-methylphosphinobutyric acid (L-MPGA) which is useful as bactericide and herbicide can be prepared by optical resolution of its racemic mixture, D,L-MPGA with the action of a microbial acylase. The process comprises providing D,L-MPGA in the form of its N-acyl derivative, reacting N-acyl-D,L-MPGA in an aqueous medium with a microbial acylase having an optically specific hydrolytic activity, whereby selectively eliminating the acyl group of N-acyl-L-MPGA to give a mixture of L-MPGA and N-acyl-D-MPGA and isolating L-MPGA from the mixture. The acylase is produced by cultivating a microbial strain belonging to the genus Pseudomonas, Streptomyces or Aspergillus, particularly Pseudomonas maltophilia BN-233, Streptomyces violascens SF 2072, Streptomyces diastatochromogenes SF 2073, Aspergillus sp. KS-101 or Aspergillus sp. KS-102.

REFERENCES:
patent: 3347752 (1967-10-01), Rauenbusch
patent: 3386888 (1968-06-01), Chibata
patent: 3527671 (1970-09-01), Zenk
patent: 3669837 (1972-06-01), Parcell
patent: 3816254 (1974-06-01), Chibata
patent: 3841966 (1974-10-01), Soichiro
patent: 3963573 (1976-06-01), Stauffer
Karger, An Introduction to Separation Science, Wiley, New York, 1973, pp. 552-554.

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