Process for the isolation and purification of epothilones

Details Process for the isolation and purification of epothilones Process for the isolation and purification of epothilones

2005-09-20

2005-09-20

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S204000

Reexamination Certificate

active

06946561

ABSTRACT:
The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the use of certain solvents for the desorption of epothilones from resins.

REFERENCES:
patent: WO 93/10121 (1993-05-01), None
patent: WO 98/22461 (1998-05-01), None
patent: WO 99/42602 (1999-08-01), None
Gerth et al., The Journal of Antibiotics, 1996, 49(6), pp. 560-563.
Nicolaou et al., “Probing the Ring Size of Epothilones: Total Synthesis of [14]-, [15]-, [17]-, and [18] Epothilones A,” Angew. Chem. Int. Ed., vol. 37, No. 1/2, pp. 81-84 (1998)*.
Nicolaou et al., “Chemical Biology of Epothilones,” Angew. Chem. Int. Ed., vol. 37, pp. 2014-2045 (1998)*.
Reichhardt C., Organic Chemistry, 2ndEd., p. 60, XP 002192137 (1988)*.
Snyder, L.R. et al., “Classification of the Solvent Properties of Common Liquids,” Journal of Chromatographic Science, vol. 16, pp. 223-234 (1978).
Robinson et al., “Liquid-Solid Chromatography on Amberlite XAD-2 and Other Styrene-Divinylbenzene Adsorbents,” Journal of Chromatography, vol. 189, pp. 145-167 (1980).

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