Process for the enzymatic preparation of enantiopure 1,...

Details Process for the enzymatic preparation of enantiopure 1,... Process for the enzymatic preparation of enantiopure 1,...

2005-05-03

2005-05-03

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C549S453000, C549S341000, C549S354000, C435S118000

Reexamination Certificate

active

06887700

ABSTRACT:
A process is provided for preparing an enantiopure 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative, which includes bringing a mixture containing enantiomeric 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivatives and an enzyme with hydrolytic activity into contact in the presence of a nucleophile. Cleaving a dioxolanone/oxathiolanone ring of one enantiomer occurs by the enzyme with hydrolytic activity and, after the cleavage of one enantiomer has taken place, the uncleaved enantiomer of the 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative is isolated.

REFERENCES:
patent: 9111186 (1991-08-01), None
patent: 9214743 (1992-09-01), None
patent: 00 22 157 (2000-04-01), None
J. Wilson et al., Bioorg. Med. Chem. Lett. 1993, 3(2), pp. 169-174.
J. Org. Chem. 1992, 57(21), pp. 5563-5565.
Chen, C.-S. et al., J. Am. Ehem. Soc. 104, pp. 7294-7299.
Patent Abstracts of Japan JP 07075594A.
Patent Abstracts of Japan JP 08023997.
Bull. Chem. Soc. Jpn. 69, pp. 2977-2987 (1996).
Hof R. P. et al., (May 7, 1996) Journal of Organic Chemistry, American Chemical Society, Easton, US, vol. 61, No. 10, pp. 3423-3427.

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