Process for the cyanation of aldehydes

Details Process for the cyanation of aldehydes Process for the cyanation of aldehydes

2005-05-24

2005-05-24

Shameem, Golam M M (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C558S303000, C558S311000, C558S315000, C502S232000, C502S242000, C502S247000

Reexamination Certificate

active

06897332

ABSTRACT:
A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with:i) a cyanide source which does not comprise a Si—CN bond or a C—(C═O)—CN moiety; andii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group;in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.

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