Process for synthesizing peptides or peptide derivatives

Details Process for synthesizing peptides or peptide derivatives Process for synthesizing peptides or peptide derivatives

1983-01-26

1986-02-25

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 70, 435183, C12P 2100, C12P 2102, C12N 900

Patent

active

045728941

ABSTRACT:
A process for synthesizing peptides or peptide derivatives is disclosed. The process involves using aminoacyl-tRNA synthetase as a condensing agent when synthesizing peptides or peptide derivatives from amino acids. According to the process, peptides or peptide derivatives which are useful as various hormones such as bradykinin having antihypertensive activity or somatostatin having an internal or external secretion controlling function and other biologically active substances such as antibiotic peptides or seasoning peptides can be produced at a moderate price without using protective groups.

REFERENCES:
patent: 3544426 (1970-12-01), Snellman
Lehninger, Albert L., Biochemistry, Worth Publishers, Inc., Chapter 30, pp. 689-694, .COPYRGT.1970.
Woodward, et al., Chapter 67c in Methods in Enzymology, Academic Press, 1974, pp. 740-746.

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