Process for synthesizing carbapenem side chain intermediates

Details Process for synthesizing carbapenem side chain intermediates Process for synthesizing carbapenem side chain intermediates

1998-06-29

2000-05-16

Stockton, Laura L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548453, 548412, 548413, 548533, 548536, C07D49508, C07F 932

Patent

active

060639318

ABSTRACT:
A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.

REFERENCES:
patent: 4340738 (1982-07-01), Sipido
patent: 5648501 (1997-07-01), Brands et al.
Brands et al., Tetrahedron Letters, vol. 37, No. 17, pp. 2919-2922, Apr. 1996.

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