Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1982-11-17
1985-08-13
Waddell, Frederick E.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2601125R, A61K 3726, C07C10352, C07G 700
Patent
active
045348944
ABSTRACT:
A process for sulphation and phosphorylation of a protein or peptide comprising contacting said protein or peptide with sulphuric or phosphoric acid in the presence of a non-aqueous apolar organic solvent and contacting the resultant solution with a dehydrating agent is disclosed. Non-aggregating insulin products with bioactivity may be prepared by this process.
REFERENCES:
Diabetologia, 1g, 1-g, (1980)--Lougheed et al.
Ind. Eng. Chem., 36 1140, (1944)--Reitz, H. C. et al.
J. Amer. Chem. Soc., 68, 1031, (1946)--Reitz, H. C. et al.
Chem. Abstr. vol. 70, (1969) 105545e.
Brownlee Michael
Cerami Anthony
Pongor Sandor
The Rockefeller University
Waddell Frederick E.
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