Process for separating pharmaceutically active diindole alkaloid

Details Process for separating pharmaceutically active diindole alkaloid Process for separating pharmaceutically active diindole alkaloid

1978-03-01

1980-06-24

Wheeler, David

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424258, C07D51904

Patent

active

042094437

ABSTRACT:
A mixture of minor diindole alkaloids from Vinca-containing vinblastine and 4-deacetoxy-vinblastine vines, are separated by subjecting the mixture to a deacetylation to correct the vinblastine to deacetyl-vinblastine prior to chromatographic separation of said mixture in a single stage.

REFERENCES:
patent: 3392173 (1968-07-01), Hargrove
patent: 3954773 (1976-05-01), Neuss et al.
patent: 3968113 (1976-07-01), Neuss et al.
Brown et al., Quantitative Chemistry, p. 457, (1964).

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