Process for production of lysine by fermentation

Details Process for production of lysine by fermentation Process for production of lysine by fermentation

1998-11-17

2000-02-15

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435 41, 435106, C12P 1308, C12P 100, C12P 1306

Patent

active

060251697

ABSTRACT:
The present invention relates to a method for controlling carbon source concentration in the aerobic cultivation of a microorganism. The substrate carbon source remains at a low level in a cultivation vessel during the culture feeding in aerobic fed-batch, continuous or cell-recycling continuous cultures. This is accomplished by monitoring the increase in pH or dissolved oxygen content in the culture medium and adding the feed solution intermittently into a cultivation vessel at a calculated feed rate using a feed control device controlled by a computer.
The present invention further relates to a process for producing L-lysine by fermentation having the advantages over the prior methods, those being improved productivity, higher concentrations of accumulated product, and increased yields of L-lysine.

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patent: 4680267 (1987-07-01), Eppstein et al.
patent: 5316905 (1994-05-01), Mori et al.
patent: 5318909 (1994-06-01), De Baere

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