Process for production of avermectins and cultures therefor

Details Process for production of avermectins and cultures therefor Process for production of avermectins and cultures therefor

1992-03-25

2000-08-15

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4351721, 4352535, 435886, C12N 120, C12P 1962, C12P 1718

Patent

active

061035041

ABSTRACT:
This invention relates to Streptomyces avermitilis lacking branched-chain amino acid transaminase activity, branched-chain 2-oxo acid biosynthetic activity and, optionally and preferably, avermectin B-O-methyl transferase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins from branched-chain fatty acid or branched-chain 2-oxo acid precursors. Such avermectins are useful as parasiticides.

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