Process for producing streptovaricin

Details Process for producing streptovaricin Process for producing streptovaricin

1991-09-26

1992-08-11

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Adaptation or attenuation of cells

435242, 4352535, 435886, 435119, C12N 136, C12P 1718, C12Q 100

Patent

active

051378256

ABSTRACT:
A method for selecting hyper-producing strains of streptovaricin C by culturing Streptomyces spectabilis and separating the asporogenous colonies. The asporogenous colonies are then separately cultured and tested for streptovaricin productivity. Those colonies having the highest productivity may then be easily selected.

REFERENCES:
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patent: 4277564 (1981-07-01), Johnson
patent: 4521516 (1985-06-01), Lemme et al.
patent: 4713241 (1987-12-01), Wakisaka et al.
K. L. Rinehart Jr. et al., "Relative Biological Activities of Individual Streptovaricins and Streptovaricin Acetates", Biochemistry, vol. 13, No. 5, pp. 861-867 (1974).
K. Sasaki et al., "Chemical Modification of Streptovaricins C," J. Antibiotics, vol. 29, No. 2, pp. 147-154 (Feb. 1976).
S. Ito et al., "Selective Killing of Human T Cell Lymphotropic Virus Type I-Transformed Cell Lines by a Damavaricin F.sub.c Derivative", J. Antibiotics, vol. 42, No. 5, pp. 779-787 (May 1989).

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