Process for producing stable sulpho-adenosyl-L-methionine salts

Details Process for producing stable sulpho-adenosyl-L-methionine salts Process for producing stable sulpho-adenosyl-L-methionine salts

1984-08-02

1986-11-04

Goldberg, Jerome D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

536 26, C12P 1928, C07H 1906

Patent

active

046210563

ABSTRACT:
A process is described for the large-scale industrial production of any stable SAMe salt at very high purity and with a yield of about 90% or more.
The new process is characterized by the following basic operations: (a) production of yeast containing 12-20 g/kg of SAMe, (b) cell lysis and recovery of the SAMe-rich lysate, (c) ultrafiltration of the lysate, (d) passage through weak acid ion exchange resin, (e) passage through absorption resin, (f) concentration by reverse osmosis, (g) spray-drying the concentrated aqueous solution of SAMe salt.

REFERENCES:
patent: 3893999 (1975-07-01), Fiecchi
patent: 3954726 (1976-05-01), Fiecchi
patent: 4057686 (1977-11-01), Fiecchi
patent: 4109079 (1978-08-01), Kawahara et al.
patent: 4242505 (1980-12-01), Kawahara et al.
patent: 4465672 (1984-08-01), Gennari
patent: 4543408 (1985-09-01), Gennari

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