Process for producing S-adenosyl-L-homocysteine

Details Process for producing S-adenosyl-L-homocysteine Process for producing S-adenosyl-L-homocysteine

1987-11-04

1991-04-16

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 43, 435 45, C12P 1440, C12P 1312, C12P 1918

Patent

active

050081888

ABSTRACT:
Process for producing S-adenosyl-L-homocysteine, which comprises reacting adenosine with homocysteine by contacting them in an aqueous medium in the presence of cells or treated cells of a microorganism of a specified genus having the ability to synthesize S-adenosyl-L-homocysteine from adenosine and homocysteine, and collecting the S-adenosyl-L-homocysteine synthesized.

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patent: 4605625 (1986-08-01), Yamada et al.
Walker et al., "S-Adenosylhomocysteine Metabolism in Various Species" Canadian Journal of Biochemistry vol. 53 pp. 312-319 (1975).
Shapiro, "Biosynthesis of Methionine from Homocysteine and S-Methylmethionine in Bacteria" Journal of Bacteriology 72 pp. 730-735 (1956).
Cantoni et al., "Activation of Methionine for Transmethylation" Journal of Biological Chemistry 225 pp. 1033-1048 (1957).
Shimizu, H. et al., (1984) Agric. Biol. Chem., vol. 48(5), pp. 1383-1385.
Chabannes, et al., "S-Adenosyl-L-Homocysteine: Simplified Enzyme Preparation With High Yield", Prep. Biochem. 12(5) pp. 395-415 (1983) Chemical Abstracts 98: 194538y.
Archives of Biochemistry & Biophysics, 69, 575 (1962), J. A. Duerre/F. Schlen, "Formation and Metabolism of S-Adenosyl-L-Homocysteine in Yeast".
J. Biol. Chem., 240, 2521 (1965), S. K. Shapiro, et al., "Biosynthesis of Methionine in Saccharomyces cerevisiae".

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