Process for producing aromatic amide compounds

Details Process for producing aromatic amide compounds Process for producing aromatic amide compounds

1994-01-18

1995-08-15

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564397, 564398, 564416, 564417, 564418, 564420, 564421, 564422, 564423, C07C23102

Patent

active

054421144

ABSTRACT:
There is disclosed a process for producing an aromatic amide compound of the general formula (4), including the steps of subjecting an o-nitrophenol compound of the general formula (1) to catalytic reduction in acetone or an aromatic hydrocarbon solvent under the presence of a nickel catalyst to give an o-aminophenol compound of the general formula (2); and (b) subjecting the o-aminophenol compound of the general formula (2) to condensation with an acid chloride compound having a sulfur content of 0.5% or less, based on the weight of the acid chloride compound, of the general formula (3) in acetone or an aromatic hydrocarbon solvent under an atmosphere of an inert gas having an oxygen concentration of 1% or less. The acid chloride compound having a sulfur content of 0.5% or less, based on the weight of the acid chloride compound, of the general formula (3) may be obtained by allowing a carboxylic acid compound of the general formula (5) to react with thionyl chloride and by concentrating the reaction mixture. Also disclosed is another process for producing an aromatic amide compound of the general formula (4), including the step of subjecting an o-aminophenol hydrochloride salt of the general formula (6) to condensation with an acid chloride compound having a sulfur content of 0.8% or less, based on the weight of the acid chloride compound, of the general formula (3) in an inert solvent.

REFERENCES:
patent: 2801171 (1957-07-01), Fierke et al.
patent: 3772002 (1973-11-01), Ramello
patent: 4126461 (1978-11-01), Pupo et al.
patent: 4500635 (1985-02-01), Aoki et al.
patent: 4686177 (1987-08-01), Aoki et al.
patent: 4990671 (1991-02-01), Dunski et al.

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