Process for producing a biochemical vaccine against Salmonella i

Details Process for producing a biochemical vaccine against Salmonella i Process for producing a biochemical vaccine against Salmonella i

1982-12-07

1985-03-05

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 68, 435253, A61K 39112, C12P 2100

Patent

active

045030367

ABSTRACT:
A bacterial vaccine against Salmonella fevers, typhoid and paratyphoid fevers is obtained by fermentation, extraction and purification, vaccinating membrane antigens being extracted by putting the bacterial residue, obtained by centrifuging, in contact with a solvent of the tris (hydroxyalkyl) aminoalkane class, with stirring, at lowered temperature, pH adjusted between 8.4 and 8.6 for a period of at least some 60 hours, then, separated by decanting, followed by purifying the antigens and fractionating by ultrafiltration, and then freeze-drying the vaccinating antigen fraction. Such vaccinating antigen fraction has a molecular weight greater than 50,000, preferably 300,000, and is used to vaccinate humans and animals.

REFERENCES:
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Chemical Abstracts, vol. 95, Abstract No. 201784u, 1981.
Biological Abstracts, vol. 63, Mar. 15, 1977, #33776, p. 3317, E. J. Johnson, Anatomical Locus of the Common Enterobacterial Antigen.
Biol. Abstracts, vol. 66 No. 4, p. 2186, #22334, Mamay et al., Outer Membrane Proteins Antigens in an Enzyme-linked Immunosorbent Assay . . . .
Chem. Abstracts, vol. 91, No. 25, 12-17-79, p. 501, No. 209139a Svenson et al., Artificial Salmonella Vaccines O-Antigenic Oligo-Saccharide . . . .
Biol. Abstracts, vol. 69, No. 2, 1980, p. 1023 Ref. #9632 #9624, Kuusi et al. Immununization with Major Outer Membrane Proteins in Experimental . . . .
Biol. Abstr., vol. 73, No. 6, 1982, Ref. 39195, Res. No. 39201, Kuusi et al., Immunization with Major Outer Membrane Protein (Porin) Preparations in Experimental . . . .
Chem. Abstracts, vol. 96, No. 5, Feb. 1, 1982, p. 313 #31280c, Tufano et al., Receptorial and Antigenic Properties of Precursor Proteins to 34K and 36K Porins . . . .

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