Process for producing 4-(2-methoxyethyl)-phenyl-glycidyl ether a

Details Process for producing 4-(2-methoxyethyl)-phenyl-glycidyl ether a Process for producing 4-(2-methoxyethyl)-phenyl-glycidyl ether a

1986-02-06

1990-09-11

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435128, 4352532, 4352533, 4352531, 435863, 435872, 435874, C12P 1702, C12P 1300, C12N 112, C12R 1365

Patent

active

049562843

ABSTRACT:
A process for the preparation of metoprolol in a stereospecific form or a non-toxic, pharmaceutically acceptable acid addition salt thereof and/or a stereospecific form of 4-(2-methoxyethyl)-phenyl glycidyl ether which comprises subjecting 4-(2-methoxyethyl)-phenyl allyl ether to the action of a microorganism having the ability for stereoselective epoxidation of 4-(2-methoxyethyl)-phenyl allyl ether into 4-(2-methoxyethyl)-phenyl glycidyl ether having at least 80% by weight the S configuration, at least partly separating 4-(2-methoxyethyl)-phenyl glycidyl ether and/or reacting 4-(2-methoxyethyl)-phenyl glycidyl ether with isopropylamine and at least partly separating metoprolol and/or converting metoprolol into its non-toxic, pharmaceutically acceptable acid addition salt.

REFERENCES:
patent: 4085136 (1978-04-01), Tucker
patent: 4368267 (1983-01-01), Hou et al.
de Smet et al., "Pseudomonas oleovorans"as a Tool in Bioconversions of Hydrocarbons: Growth, Morphology and Conversion Characteristics in Different Two Phase Systems, Enz Microb Techol., 5, 352-360, 1983.
Gelb et al., "Cytochrome P450.sub.cam Catalized Epoxidation of Dehydrocamphor", Biochem. and Biophy. Res. Comm. 104, 853-858, 1982.
Morrison et al., Organic Chemistry 1980, pp. 119 and 130.
Ohta et al., Agric. Biol. Chem. 1979, vol. 43, pp. 2099-2104.
ATCC Catalog, 1985, pp. 52 and 150.

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