Process for producing 3-amino-2-oxo-1-halogenopropane derivative

Details Process for producing 3-amino-2-oxo-1-halogenopropane derivative Process for producing 3-amino-2-oxo-1-halogenopropane derivative

1996-11-18

1998-06-16

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560 29, 568306, C07C22302

Patent

active

057673160

ABSTRACT:
Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-amino-3-oxo-2-halogenobutanoic acid ester derivative, and hydrolysis and decarboxylation are conducted to produce a 3-amino-2-oxo-1-halogenopropane derivative or its salt. The present method is a useful process for producing a 3-amino-2-oxo-1-halogenopropane derivatives which can easily be converted to a 3-amino-1,2-epoxypropane.

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