Process for producing 1,2-epoxy-3-amino-4-phenylbutane derivativ

Details Process for producing 1,2-epoxy-3-amino-4-phenylbutane derivativ Process for producing 1,2-epoxy-3-amino-4-phenylbutane derivativ

1997-08-08

1999-08-10

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30338

Patent

active

059361042

ABSTRACT:
The present invention provides a process for producing 1,2-epoxy-3-amino-4-phenylbutane derivatives which comprises treating a 1-halo-2-hydroxy-3-amino-4-phenylbutane derivative with a base in an aprotic polar organic solvent or a mixed solvent composed of an aprotic polar organic solvent and water and then causing the resulting epoxide to crystallize out from a mixed solvent composed of an aprotic polar organic solvent and water.

REFERENCES:
patent: 5550291 (1996-08-01), Beaulieu et al.
patent: 5610190 (1997-03-01), Talley et al.

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