Method of preparing 7-oxabicycloheptyl substituted heterocyclic

Details Method of preparing 7-oxabicycloheptyl substituted heterocyclic Method of preparing 7-oxabicycloheptyl substituted heterocyclic

1993-10-04

1994-09-13

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483114, 548525, 549463, C07D21336, C07D23360

Patent

active

053470079

ABSTRACT:
A method is provided for preparing 7-oxabicycloheptyl substituted heterocyclic aide prostaglandin analogs which are thromboxane A.sub.2 (TXA.sub.2) receptor antagonists or combined thromboxane A.sub.2 receptor antagonists/thromboxane synthetase inhibitors useful, for example, in the treatment of thrombotic and/or vasospastic disease, wherein a vinyl bromide of the formula, for example, ##STR1## wherein m, n, R.sup.1 and R.sup.2 are as defined herein is treated with a cyclizing agent to forth the corresponding oxazole.

REFERENCES:
patent: 5100889 (1992-03-01), Misra et al.
patent: 5158967 (1992-10-01), Hall
Chung-gi Shin, et al, ".alpha.,.beta.,-Unsaturated Carboxylic Acid Derivatives, XII. A Convenient Synthesis of Oxazole-4-carboxylic and 3,3-Dibromo-2,2-diamino Acids 1" Bull. of the Chem. Society of Japan, Vo, 50 (7), 1788-1793 (1977).
CA 114:164202r Preparation of . . . vasorelaxants. Misra, p. 776, 1991.
CA 118(21):212942p Novel methods . . . Bromides. Das et al., p. 904, 1993.

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