Process for preparing pyrrole derivatives and intermediates

Details Process for preparing pyrrole derivatives and intermediates Process for preparing pyrrole derivatives and intermediates

2011-04-26

2011-04-26

Chu, Yong (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S531000, C548S562000, C548S563000

Reexamination Certificate

active

07932403

ABSTRACT:
The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).

REFERENCES:
patent: 5969156 (1999-10-01), Briggs et al.
patent: 6867306 (2005-03-01), Srinath et al.
patent: 2004/0259880 (2004-12-01), Lockhart et al.
patent: WO03/004457 (2003-01-01), None
patent: WO03/044011 (2003-05-01), None
patent: WO2004/106299 (2004-12-01), None
patent: WO2005/012246 (2005-02-01), None
patent: WO2005/118536 (2005-12-01), None
Patini et al, Chem Rev, 1996, 3147-3176, esp. p. 3150.
Graul, A et al., Drugs of the Future, vol. 22(9): 956-968 (1997).
Pandey, PS et al., Bioorganic & Medicinal Chemistry Letters, vol. 14(1): 129-131 (Jan. 2004).
Procopiou, PA et al., Journal of Medicinal Chemistry (ACS), vol. 36(23): 3658-3662 (1993).
Roth, BD et al., Journal of Medicinal Chemistry (ACS), vol. 34(1): 357-366 (Jan. 1991).
International Search Report for PCT/EP05/013588 (PCT/ISA/210).
Written Opinion of the International Searching Authority for PCT/EP05/013588 (PCT/ISA/237).

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